4 Major Depressive Disorder (MDD) patients received 808 nm infrared laser treatment at 84 J/cm^2 at 4 sites transcranially. At 6 weeks post irradiation they had healthier Hamilton Depression Rating Scale scores on 17 items.
Ten patients with Major Depressive Disorder (MDD) received 810 nm LED treatment transcranially at 60 J/cm^2. Researchers measured decreased depression and anxiety according to the Hamilton Depression Rating Scale. They did not find changes in cerebral blood flow.
A 2017 study in Photomedicine and Laser Surgery found improved dementia symptoms after 810 nm infrared transcranial and intranasal irradiation of five patients using Vielight 810 and Neuro LED devices. Patients received 10.65 J/cm2 from 14.2 mW/cm^2 or 24.6+13.8 J/cm^2 from 41+23 mW/cm^2. Treatment times for 25 or 20 minutes. The devices output 10 Hz pulsed wave. The study lasted 12 weeks. Vielight 810 is an intranasal device. The Neuro is transcranial and intranasal. Light reached “bilateral mesial prefrontal cortex, precuneus/posterior cingulate cortex, angular gyrus, and hippocampus.” Results included dementia improvement of sleep, fewer angry outburts, reduced anxiety and reduced wandering.
11 dementia patients received 1060 nm to 1080 nm infrared pulsed at 10 Hz LED treatment for 6 minutes a day for 28 days. They wore a brain helmet irradiating the brain from all directions. Researchers found improved executive functioning, recall, visual attention and task switching, as well as improved EEG amplitude.
89 Alzheimer’s patients received a range of wavelengths in the visible spectrum (25-1000 nm) for 20 to 40 minutes, with continuous or pulsed wave laser. Researchers inserted a fiber optic through a femoral artery catether to deliver light to the cerebral arteries. Analysis showed improved microcirculation, cognitive recovery and decreased dementia.
A stroke victim received 660 nm and 850 nm irradiation to 32 sites on the head, brainstem, spine and musculature from a 1400 mW device delivering 2.95 J/cm^2. Each site received treatment for 1 minute, 1 time per week for 8 weeks. The author found improvements in cognitive and physical deficits.
120 acute stroke patients received 808 nm transcranial laser within 24 hours of onset. Each received 1.2 J/cm^2 at the cortext for 2 minutes on 20 sites on a shaved scalp. Analysis found improvement based on the NIH Health Stroke Scale, modified.
Five traumatic brain injury patients with cognitive disabilities received transcranial 785 nm infrared laser 5 times per week for 6 weeks. They showed improved awareness and alertness, but two epileptic fits corresponded with treatment earlier that day. The fits also corresponded with concurrent antibiotic treatments.
10 chronic TBI patients received 810 nm and 980 nm infrared laser treatment of 14.8 to 28.3 J/cm^2 2 to 3 times per week for 8 weeks. Treatments were pulsed at 10 Hz. Transcranial treatment spots included 2 sites on the forehead and 3 bilateral, prefrontal and temporal. At measurement they showed improved headaches, sleep disturbances, cognition, mood regulation, anxiety and irritability.
11 chronic traumatic brain injury patients were treated with 633 nm and 870 nm infrared three times per week for six weeks. They received 13 J/cm^2 transcranially on 11 sites at midline and bilateral forehead. At 6 weeks they experience better sleep, decreased PTSD and improved social performance.