Because depression and anxiety have “common psychiatric comorbidities in epilepsy,” researchers tested depression treatment with light on epileptic patients. 101 subjects had “medically intractable focal epilepsy.” Researchers treated 51 subjects with a high-intensity light box, and 50 subjects with a low-intensity light box. Each subject received one treatment per day. Only 58 subjects completed the trial. Depression and anxiety scores were significantly better for both groups. The study included no placebo controls.
One 23-year old traumatic brain injury patient complained of headaches, anxiety, and difficulty concentrating. He home-treated with a Vielight Neuro Duo. At an 8 week measurement he had increased brain volume, improved functional connectivity, increased cerebral perfusion, and neuropsychological improvements.
A 2017 study in Photomedicine and Laser Surgery found improved dementia symptoms after 810 nm infrared transcranial and intranasal irradiation of five patients using Vielight 810 and Neuro LED devices. Patients received 10.65 J/cm2 from 14.2 mW/cm^2 or 24.6+13.8 J/cm^2 from 41+23 mW/cm^2. Treatment times for 25 or 20 minutes. The devices output 10 Hz pulsed wave. The study lasted 12 weeks. Vielight 810 is an intranasal device. The Neuro is transcranial and intranasal. Light reached “bilateral mesial prefrontal cortex, precuneus/posterior cingulate cortex, angular gyrus, and hippocampus.” Results included dementia improvement of sleep, fewer angry outburts, reduced anxiety and reduced wandering.
10 chronic TBI patients received 810 nm and 980 nm infrared laser treatment of 14.8 to 28.3 J/cm^2 2 to 3 times per week for 8 weeks. Treatments were pulsed at 10 Hz. Transcranial treatment spots included 2 sites on the forehead and 3 bilateral, prefrontal and temporal. At measurement they showed improved headaches, sleep disturbances, cognition, mood regulation, anxiety and irritability.