Light Dose Database

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This is the EMF Channel database of light therapy study doses. After getting the results, click to view more study details. Only successful studies are included. 99% of the studies here are on humans, not animals. This database is a work in progress. Many thanks to Vlad for his PBM database. When the data here references his work, the detail page includes a link to the PBM spreadsheet.

Red light therapy brain dose

Infrared Sinus Delivery the Most Efficient Choice to Stimulate the Brain

Journal:

Red and NIR light dosimetry in the human deep brain

Wavelength:
808, 671
Irradiance:
1
Condition:
Cognition, Dementia/Alzheimers, Parkinson's
Outcome:

Researchers tested 671 nm and 808 nm 1 mW/cm^2 laser photon delivery in a severed cadaver head. They compared sinus (transsphenoidal), oral, and head (transcranial) light delivery at both wavelengths. 808 delivered more energy than 671 to a 40 mm target inside the brain tissue. They found that sinus delivery delivered 20 times more photons than transcranial delivery. Comparing oral, sinus and head delivery, and comparing 671 nm to 808 nm delivered at the same power density, the 808 nm diode transferred the largest quantity of photons to the farthest parts of the brain.

Red light therapy brain dose

Significant Gulf War Illness (Chronic Multisymptom Illness) Improvements after 12 Weeks of Vielight Neuro Alpha Treatment

Journal:

Improvements in Gulf War Illness Symptoms After Near-Infrared
Transcranial and Intranasal Photobiomodulation: Two Case
Reports

Wavelength:
810
Irradiance:
100, 75 and 25 mW/cm^2
Condition:
Anxiety, Cognition, Depression, Memory, Pain, Headache, PTSD
Outcome:

Researchers tested the effects of the Vielight Neuro Alpha photobiomodulation device on Gulf War Illness (GWI) symptoms. GWI symptoms include persistent headaches, cognitive difficulties, joint pain, musculoskeletal pain, fatigue, gastrointestinal problems. Because the pattern can present in non-Gulf War veterans, the phenomenon is also called Chronic Multisymptom Illness (CMI). A CMI diagnosis is 6 months of symptoms in at least two of these categories: fatigue, pain, and cognitive-mood. A Kansas GWI is moderately severe or multiple chronic symptoms in at least three of these categories: fatigue/sleep problems, pain, neurological/
cognitive/mood problems, respiratory problems, gastrointestinal problems, and skin problems.

Subjects took self-assessment questionnaires and cognitive tests. They tested before treatment and at the 12-week mark. Gulf War Veteran 1 (GWV1) presented as a Kansas GI. Gulf War Veteran 2 (GWV2) presented as Kansas GWI. Subjects used the Vielight Neuro Alpha device daily for 12 weeks. The device delivers:

  • 810 nm 100 mW/cm^2 pulsed at 10 Hz to 3 posterior transcranial targets
  • 810 nm 75 mW/cm^2 pulsed at 10 Hz to an anterior target
  • 810 nm 25 mW/cm^2 pulsed at 10 Hz to an intranasal passage

At 12 weeks both subjects improved on multiple scores. GWV1 no longer qualified as Kansas GWI. He was re-categorized as mild-moderate CMI. GWV1 showed improvements in mood-cognitive, pain, sleep and fatique categories.

GWV2 was re-categorized from severe CMI to mild-moderate CMI. He showed improvements in fatique, pain and mood-cognitive scores.

Red light therapy brain dose

Vielight Treatment Measurable Brain Improvements in N=1 Traumatic Brain Injury Patient

Journal:

Changes in Brain Function and Structure After Self-Administered Home Photobiomodulation Treatment in a Concussion Case

Wavelength:
810
Irradiance:
Condition:
Cognition, Traumatic Brain Injury
Outcome:

One 23-year old traumatic brain injury patient complained of headaches, anxiety, and difficulty concentrating. He home-treated with a Vielight Neuro Duo. At an 8 week measurement he had increased brain volume, improved functional connectivity, increased cerebral perfusion, and neuropsychological improvements.

Red light therapy brain dose

Parksinson’s Mobility, Balance and Cognition Improvements with Brain Photobiomodulation

Journal:

Improvements in clinical signs of Parkinson’s disease using photobiomodulation: A prospective proof-of-concept study

Wavelength:
810
Irradiance:
Condition:
Cognition, Parkinson's
Outcome:
  • Vielight Gamma 4 LEDs, 240 joules, four transcranial targets
  • Vielight Gamma 1 LED, 15 joules, one intranasal target
  • Irradia MID 2.5 4 Laser Diodes, 39.6 joules, or MIDCARE laser, 2 diodes, 39.6 joules, C1/C2 neck region and abdomen

 

Group 1 Schedule:

  • Weeks 1-4: 3x/week
  • Weeks 5-8: 2x/week
  • Weeks 9-12: 1x/week
  • Weeks 13-40: 3x/week

Group 2 Schedule:

  • Weeks 13-25: 3x/week

Groups were tested before and after PBM treatment on measures:

  • Functional Mobility task of Time Up and Go (TUG): Stand, walk 3 m, turn, return, sit down
  • Gait TUG Motor: First task plus carrying water
  • Gait TUG Cognitive: First task plus counting backwards in twos
  • Gait TUG 10 Meter Walk: Time to walk 14 meters after having already walked 2 meters
  • Gait TUG 10 Meter Stride: Number of strides to walk last 6 m of task above
  • Dynamic Balance Step Test: Number of times patient used a step for balance
  • Cognition Montreal Cognitive Assessment: Standardized cognition test
  • Fine Motor Skills Spiral Test: Drawing within the lines
  • Fine Motor Skills Nine Hole Peg: Put pegs in holes, return pegs to bin
  • Fine Motor Skills Micrographia: Handwriting area taken per word
  • Static Balance Tandem Stance: Duration of standing with one foot ahead of the other
  • Static Balance Single Leg Stance: Duration of standing with one foot in the air

 

Participants in both groups saw significant improvement in functional mobility, dynamic balance, and cognition. Results were good but not significant for fine motor skills and static balance.

Red light therapy brain dose

Improve Coma Patient Alertness after 785 nm Transcranial Laser Treatments

Journal:

Neuroplastic effects of transcranial near-infrared stimulation (tNIRS) on the motor cortex

Wavelength:
785
Irradiance:
10
Condition:
Cognition, Coma
Outcome:

16 comatose patients received 785 transcranial 785 nm infrared laser treatments five timers a week for four weeks. Post treatment measurement showed improved alertness, and improved awareness over time.

Red light therapy brain dose

Transcranial 850 nm Infrared Treatment of Vegatative Patient Yields Blood Flow and Neurological Improvement

Journal:

Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state

Wavelength:
850
Irradiance:
11.4
Condition:
Cognition, Coma
Outcome:

A researcher treated a vegatative patient with 850 nm infrared LED 20.5 J/cm^2 for 30 min, 2 times per day, for 73 days. The transcranial treatment included 2 sites at the left and right of the forehead above the eyebrows. At measurement the patient had increased blood flow in the treated area and better neurological outcomes..

Red light therapy brain dose

Transcranial 1064 nm Infrared Treatment Improves Depression

Journal:

Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms

Wavelength:
1064
Irradiance:
250
Condition:
Cognition, Depression
Outcome:

51 patients with elevated depression symptoms received 1064 nm infrared transcranial laser treatments over two sessions. Researchers concluded that “right prefrontal irradiation improved attention bias modification intervention effects and depression symptoms.”

Red light therapy brain dose

Transcranial 808 nm High Dose Infrared Significantly Improves Major Depressive Disorder Rating Scores

Journal:

Near-Infrared Transcranial Radiation for Major Depressive Disorder: Proof of Concept Study

Wavelength:
808
Irradiance:
5000 and 700
Condition:
Cognition, Depression, Emotion
Outcome:

4 Major Depressive Disorder (MDD) patients received 808 nm infrared laser treatment at 84 J/cm^2 at 4 sites transcranially. At 6 weeks post irradiation they had healthier Hamilton Depression Rating Scale scores on 17 items.

Red light therapy brain dose

810 nm Infrared Transcranial LED Treatment Corresponds with Decreased Depression Scores

Journal:

Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety

Wavelength:
810
Irradiance:
250
Condition:
Cognition, Depression
Outcome:

Ten patients with Major Depressive Disorder (MDD) received 810 nm LED treatment transcranially at 60 J/cm^2. Researchers measured decreased depression and anxiety according to the Hamilton Depression Rating Scale. They did not find changes in cerebral blood flow.

Red light therapy brain dose

Vielight 810 and Neuro Intranasal and Transcranial Infrared LED Significantly Decreases Dementia Symptoms

Journal:

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report

Wavelength:
810
Irradiance:
14.2 or 41+23
Condition:
Cognition, Dementia/Alzheimers
Outcome:

A 2017 study in Photomedicine and Laser Surgery found improved dementia symptoms after 810 nm infrared transcranial and intranasal irradiation of five patients using Vielight 810 and Neuro LED devices. Patients received 10.65 J/cm2 from 14.2 mW/cm^2 or 24.6+13.8 J/cm^2 from 41+23 mW/cm^2. Treatment times for 25 or 20 minutes. The devices output 10 Hz pulsed wave. The study lasted 12 weeks.  Vielight 810 is an intranasal device. The Neuro is transcranial and intranasal. Light reached “bilateral mesial prefrontal cortex, precuneus/posterior cingulate cortex, angular gyrus, and hippocampus.” Results included dementia improvement of sleep, fewer angry outburts, reduced anxiety and reduced wandering.

Red light therapy brain dose

Whole Head Infrared LED Treatment Significantly Improves Dementia Measurements

Journal:

Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition

Wavelength:
1060, 1080
Irradiance:
Condition:
Cognition, Dementia/Alzheimers
Outcome:

11 dementia patients received 1060 nm to 1080 nm infrared pulsed at 10 Hz LED treatment for 6 minutes a day  for 28 days. They wore a brain helmet irradiating the brain from all directions. Researchers found improved executive functioning, recall, visual attention and  task switching, as well as improved EEG amplitude.

Red light therapy brain dose

Invasive Femoral Artery Laser Fiber Optic Irradiation Improves Alzheimer’s Symptoms

Journal:

Dementia and Cognitive Impairment Reduction after Laser Transcatheter Treatment of Alzheimer’s Disease

Wavelength:
Range
Irradiance:
20
Condition:
Cognition, Dementia/Alzheimers
Outcome:

89 Alzheimer’s patients received a range of wavelengths in the visible spectrum (25-1000 nm) for 20 to 40 minutes, with continuous or pulsed wave laser. Researchers inserted a fiber optic through a femoral artery catether to deliver light  to the cerebral arteries. Analysis showed improved microcirculation, cognitive recovery and decreased dementia.

Red light therapy brain dose

Stroke Improvement on N=1 Patient Receiving 660 nm Red and 850 nm Infrared Therapy

Journal:

A new treatment protocol using photobiomodulation and muscle/bone/joint recovery techniques having a dramatic effect on a stroke patient’s recovery: a new weapon for clinicians

Wavelength:
660, 850
Irradiance:
1400
Condition:
Cognition, Stroke
Outcome:

A stroke victim received 660 nm and 850 nm irradiation to 32 sites on the head, brainstem, spine and musculature from a 1400 mW device delivering 2.95 J/cm^2. Each site received treatment for 1 minute, 1 time per week for 8 weeks. The author found improvements in cognitive and physical deficits.

Red light therapy brain dose

Transcranial 808 nm Infrared Laser Treatment Improves Stroke Outcomes Not Repeatable

Journal:

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1)

Wavelength:
808
Irradiance:
10
Condition:
Cognition, Stroke
Outcome:

120 acute stroke patients received 808 nm transcranial laser within 24 hours of onset. Each received 1.2 J/cm^2 at the cortext for 2 minutes on 20 sites on a shaved scalp. Analysis found improvement based on the NIH Health Stroke Scale, modified.

Red light therapy brain dose

Severe Brain Damage Transcranial Laser Brings Improvement, Epileptic Fits

Journal:

Transcranial Low-Level Laser Therapy May Improve Alertness and Awareness in Traumatic Brain Injured Subjects with Severe Disorders of Consciousness: a Case Series

Wavelength:
785
Irradiance:
10
Condition:
Cognition, Traumatic Brain Injury
Outcome:

Five traumatic brain injury patients with cognitive disabilities received transcranial 785 nm infrared laser 5 times per week for 6 weeks. They showed improved awareness and alertness, but two epileptic fits corresponded with treatment earlier that day. The fits also corresponded with concurrent antibiotic treatments.

Red light therapy brain dose

Chronic TBI Infrared Laser Transcranial Treatment

Journal:

Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy

Wavelength:
810, 980
Irradiance:
10 and 15 WATTS
Condition:
Cognition, Depression, Emotion, PTSD
Outcome:

10 chronic TBI patients received 810 nm and 980 nm infrared laser treatment of 14.8 to 28.3 J/cm^2 2 to 3 times per week for 8 weeks. Treatments were pulsed at 10 Hz. Transcranial treatment spots included 2 sites on the forehead and 3 bilateral, prefrontal and temporal. At measurement they showed improved headaches, sleep disturbances, cognition, mood regulation,  anxiety and irritability.

Red light therapy brain dose

Chronic Traumatic Brain Injury, Depression, PTSD, Social Anxiety Transcranial LED Treatment

Journal:

Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study

Wavelength:
633, 870
Irradiance:
19.39 and 22.48
Condition:
Cognition, Depression, Emotion, PTSD
Outcome:

11 chronic traumatic brain injury patients were treated with 633 nm and 870 nm infrared three times per week for six weeks. They received 13 J/cm^2 transcranially on 11 sites at midline and bilateral forehead. At 6 weeks they experience better sleep, decreased PTSD and improved social performance.

Red light therapy brain dose

Red and Infrared LED Treatment for Traumatic Brain Injury, Depression and PTSD Case Report

Journal:

Improved Cognitive Function After Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports

Wavelength:
633, 870
Irradiance:
19.39 and 22.48
Condition:
Cognition, Depression, PTSD
Outcome:

Two Chronic Traumatic Brain Injury (TBI) patients who also had depression or post trauamtic stress disorder (PTSD) symptoms  received 633 nm red and 870 nm transcranial light treatment of 13.3 J/cm^2 10 minutes per site, 1x/weeek for 6 years, or 1x/day for 4 months. Researchers treated bilateral left and right forehead (“and multiple other areas”).  At the time of measurement, each had improved executive function, memory and PTSD symptoms.

Red light therapy brain dose

850 nm Transcranial Infrared LED Improves Attentional Performance

Journal:

Beneficial Effects of Transcranial Light Emitting Diode (LED) Therapy on Attentional Performance: An Experimental Design

Wavelength:
850
Irradiance:
285
Condition:
Cognition
Outcome:

39 healthy volunteers received 60 J/cm^2 of 850 nm infrared LED transcranially. They experienced improved attentional performance in the Go/No task.

Red light therapy brain dose

903 nm Transcranial Infrared LED Light Improves qEEG Reaction Time

Journal:

Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures

Wavelength:
903
Irradiance:
16.67
Condition:
Cognition
Outcome:

In a 2017 study, 31 healthy volunteers received 903 nm LED LumiWave light transcranially. They experienced improved reaction time in the qEEG event-related response test.

Red light therapy brain dose

627 nm Transcranial Red Light Increases Cranial Artery Blood Velocity

Journal:

The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women

Wavelength:
627
Irradiance:
70
Condition:
Cognition
Outcome:

In a 2015 study, 25 healthy elderly women received 627 nm LED light transcranially at four sites, two times per week for four weeks. They experienced increased cerebral artery velocity at both systolic and idastolic measurements.

Red light therapy brain dose

Transcranial Infrared Treatment Improves Pre-Frontal Rule Based Learning

Journal:

Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures

Wavelength:
1064
Irradiance:
250
Condition:
Cognition
Outcome:

Blanco et al. 2017 [210] Healthy volunteers (118) Laser, CG-5000, Cell
Gen Therapeutics, LLC (Dallas, TX, USA) 1064 nm 250 mW/cm2, 60 J/cm2, 8 min, one irradiation session, CW Transcranially;
2 sites, lower and upper portion of right lateral forehead at EEG map sites: FP2, F4, and F8 sites Improved prefrontal rule-based learning; no significant effects on information-integration learning

Red light therapy brain dose

Transcranial Infrared Increased Brain Blood Oxygenation

Journal:

Transcranial laser stimulation improves human cerebral oxygenation

Wavelength:
1064
Irradiance:
250
Condition:
Cognition
Outcome:

In a 2016 study 12 healthy volunteers were irradiated with a 1064 nnm laser light dose of 13.75 J/cm^2 per minute for 10 minutes. Light shone on the center forehead and right side. Treated subjects exhibited higher oxygen concentration in hemoglobin across the two hemispheres. Oxygenation increased during treatment and continued at least 6 minutes after.

Red light therapy brain dose

Transcranial Infrared Improves Executive Function Scores

Journal:

Improving executive function using transcranial infrared laser stimulation

Wavelength:
1064
Irradiance:
250
Condition:
Cognition
Outcome:

In a 2015 study 30 healthy volunteers received 60 J/cm^2  1064 nm irradiation on two forehead sites. They showed improved executive function after treatment.

Red light therapy brain dose

Infrared Transcranial Treatment Improves Vigilance, Memory and Mood Scores

Journal:

Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans

Wavelength:
1064
Irradiance:
250
Condition:
Cognition, Emotion
Outcome:

In a 2013 study researchers irradiated 40 healthy volunteers with 60 J/cm^2 1064 nm continuous laser light for 4 minutes. Targets are 2 unilateral transcranial sites: the right frontal pole on 4 cm medial and lateral. The treated group have improved Psychomotor Vigilance Task reaction time, improved memory task scores and a positive mood when measured 2 weeks after treatment.

Red light therapy brain dose

Laser Infrared on Palm Changes Brainwave Amplitude

Journal:

Effect of Low-Level Laser Stimulation on EEG

Wavelength:
830
Irradiance:
42 mW
Condition:
Cognition, Depression, Brainwave
Outcome:

In a 2012 study researchers irradiated 40 healthy volunteers with 830 nm infrared laser light with a dose of 7 mW/diode, 6 diodes, 20 J/cm^2, 10 minutes, pulsed at 10 Hz on the left palm

The treatment increased alpha and theta amplitude in the posterior head region, and decreased beta amplitude in the anterior head region.

Science study Red light therapy skin dose

Acne Reduction with 415 nm Blue and 660 nm Light Therapy

Journal:

Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris

Wavelength:
415, 660
Irradiance:
Condition:
Acne
Outcome:

Subjects received a monochromatic 415 nm blue treatment, or a polychromatic 415 nm and 660 nm treatment. Groups 3 and 4 received cool white light and 5% benzyl peroxide. Patients treated themselves 1x/day for 15 minutes for 12 weeks. At weeks 4 and 8, the red and red-blue groups achieved similar lesion reductions. At week 12, the blue-red group had significantly better results than blue alone. The blue-red group had a 76% inflammatory lesion reduction, significantly higher than the blue light, white light, and benzyl peroxide treatment.

In cataloguing this study, the “cool white light” is classified as having “unknown” wavelengths.

Science study Red light therapy skin dose

Acne Treatment Using 415 nm and 633 nm LED Therapy

Journal:

Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris

Wavelength:
415, 633
Irradiance:
Condition:
Acne
Outcome:

24 mild to severe acne patients with Fitzpatrick skin types II-V received 415 nm blue at one session alternating with 633 nm red at the next. Schedule was 2x/week, 3 days apart, 20 min. per session, 48 J/cm^2 415 nm or 96 J/cm^2 633 nm. All subjects had mild microabrasions before treatment. 22 patients were assessed, 2 dropped out. Researchers objectively counted a 46% lesion count reduction at 4 weeks, and an 81% lesion count reduction at 12 weeks.

Science study Red light therapy skin dose

Treating Acne and Rosacea with Chromophore Gel with Broadband Light

Journal:

FLUORESCENT LIGHT ENERGY: The Future for Treating Inflammatory Skin Conditions?

Wavelength:
470, 590, 630, 660, 850, 870, 890, 505, 405, 375, 450, 525, 570, 645, 700, 940, 970
Irradiance:
Condition:
Acne
Outcome:

Photodynamic Light Therapy

When applied with a topical substance, light therapy becomes photodynamic therapy (PDT). Kleresca is a photodynamic therapy treatment manufacturer based in Europe and Australia.

Kleresca marketing refers to this process as biophotonics. In home LED therapy, the chromophores in the mitochondria absorb the photons to create an ATP and nitric oxide response. In PDT, the topical substance absorbs the photons. Then, the substance is potentiated to heal, or the absorption transfers photon energy to the skin. In this case, it appears that the chromophore gel is a mediator to get more photons to the skin.

This study looked at the Kleresca chromophore gel’s light absorption properties.
Researchers tested gel penetration of fluorescent light energy (FLE) of 375 nm, 405 nm, 435 nm, 450 nm, 470 nm, 505 nm, 525 nm, 570 nm, 590 nm, 630 nm, 645 nm, 660 nm, 700 nm, 850 nm, 870 nm, 890 nm, 940 nm and 970 nm.
They tested the reflection and absorption qualities of the gel with each color. They found that 375 nm had the highest reflectance. 405 nm through 590 nm had the highest absorption. 630 nm through 970 nm had less but still significant absorption. In other words, at least 5 wavelengths between 405 nm and 590 nm deeply penetrate the chromophore gel; at least nine red and infrared wavelengths significantly penetrate the gel. 375 nm is a high reflectance outlier. The gel maintained fluorescence for up to 15 minutes after exposure.

The fluorescent Kleresca lamp output similar irradiance to an LED analogue. Irradiance for both lamps peaked at just under 10 mW/cm^2 and 435 nm. Irradiance was lowest at 500 nm to 550 nm at .01 mW/cm^2 (LED) and .001 mW/cm^2 (Kleresca). Lamps peaked output again at 570 nm at just under .1 mW/cm^2 and plummeted back to 0.001 between 630 nm and 700 nm.

Authors tested Kleresca PDT on one acne patient. Inflammation reduction peaked at week 20 and corresponded with significant lesion reduction. More acne resolution occurred from week 21 to week 57 with visible reductions at week 33, week 45 and week 57.

A third test compared fibroblast collagen production under LED and Kleresca. Kleresca produced more collagen compared to LED in untreated skin. In part 2 of the collagen test, researchers added interferon inflammatory markers to the fibroblast cells. LED collagen production remained consistent, but FLE dramatically fell below LED results. In the presence of inflammatory marker, LED produced the same collagen, and FLE produced significantly less collagen.

In a confusing statement of conflict, the authors state that they Kleresca employees, but that Kleresca did not fund the study, and there are no conflicts of interest.

Science study Red light therapy skin dose

Treating Acne with Alternating Red Light Therapy with Blue Light Therapy

Journal:

A Comparative Study Between Once-Weekly and Alternating Twice-Weekly Regimen Using Blue (470 nm) and Red (640 nm) Light Combination LED Phototherapy for Moderate-to-Severe Acne Vulgaris

Wavelength:
470, 640
Irradiance:
Condition:
Acne
Outcome:

Both groups had moderate to severe acne. All subjects received 470 nm blue and 640 nm red light therapy treatments. Group 1 received treatment two times per week for four weeks. At the first weekly session, they received one color treatment. At the second weekly session they received the other color treatment. Group 2 received treatment one time per week. At this session, they first received one color, then they received the second color. Group 1 treatment was spread across two days. Group 2 treatment was delivered in one day. Both groups had significant lesion count reduction, and were not significantly different from one another. Both regimens had significant results.

Science study Red light therapy skin dose

Blue and Red Light Equal at Treating Psoriasis, Blue Better at Reducing Redness

Journal:

Efficacy of blue light vs. red light in the treatment of psoriasis: a double-blind, randomized comparative study

Wavelength:
420, 630
Irradiance:
Condition:
Psoriasis
Outcome:

Researchers treated psoriasis patients without treating it with any photosensitizers. Protoporphyrin IX (PpIX) is an endogenous photoreceptor. Both 420 nm blue and 630 nm red equally reduced psoriasis symptoms. Blue reduced redness more than red.

Science study Red light therapy skin dose

Blue Light, Red Light, and Topical Curcumin Treat Psoriasis

Journal:

Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin

Wavelength:
630, 660, 405
Irradiance:
Condition:
Psoriasis
Outcome:

Researchers combined topical curcumin with 405 nm blue light, and then either 630 nm or 660 nm red light. Both treatment groups showed significant decrease in symptoms. The treatments decreased keratinocytes cell proliferation, which is the primary causative factor in psoriasis symptoms.

Science study Red light therapy skin dose

453 nm Blue Light Treats Eczema

Journal:

Prospective, Randomized Study on the Efficacy and Safety of Local UV-Free Blue Light Treatment of Eczema

Wavelength:
432
Irradiance:
Condition:
Eczema
Outcome:

21 patients with mild to moderate eczema were treated with LED 453 nm 3x/week for 4 weeks. All patients had statistically significant improvements on the Eczema Severity Index (ESI).

Green light therapy fat loss dose

590 nm Light Effect on Lipid Droplets and Hormone-Sensitive Lipase

Journal:

Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes

Wavelength:
590, 660, 410, 457, 505, 530
Irradiance:
Condition:
Fat
Outcome:

Researched irradiated human fat with 410 nm, 457 nm, 505 nm, 530 nm, 590 nm, and 660 nm low level light. 590 nm “significantly reduced the concentration of lipid droplets” and increased lipid autophagy (broke down fat). In documenting the science of photobiomodulation, I rarely come across a study that finds significant effect at one wavelength, and no effect at nearby wavelengths. That did happen in this study. 590 nm affected fat breakdown and 505 nm did not. The abstract did not mention the other wavelengths tested. Presumably they were also insignificant, so it’s unclear why 505 nm was singled out as ineffective.

red light therapy for hair growth dose

Combining 590 nm Light with Minoxidil to Increase Hair Growth

Journal:

Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% to Bring a Sustainable Hair Regrowth Activity

Wavelength:
590
Irradiance:
Condition:
Hair Growth
Outcome:

Researchers tested low level light therapy to see if it would reduce scalp inflammation that interferes with hair re-growth. They tested the L’Oréal LLLT/GentleWaves® device’s effect on hair growth. 64 men with androgenetic alopecia received 590 nm for 70 seconds (pulsed) 1x/day for 3 days. Their scalps were DNA squenced. Then they tested the device as well as Minoxidil on 135 men and women with alopecia. The 590 nm treatment correlated with downregulation of sclap inflammatory biomarkers in half the treated subjects. The second study showed increase Minoxidil hair growth. Those receiving 2% Minoxidil responded as if they had received 5% Minoxidil.

Red light therapy eye sight dose

Yellow, Red and Infrared Improves Dry Age-Related Macular Degeneration

Journal:

Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration

Wavelength:
590, 670, 790
Irradiance:
Condition:
Eyesight, Macular Degeneration
Outcome:

Researchers treated 42 eyes with 590 nm, 670 nm and 790 nm LED light over 3 weeks. Patients experienced improved scores on “best-corrected visual acuity (BCVA), contrast sensitivity (CS), drusen volume and central drusen thickness” at either 3 week or 3 month testing.

Science study Red light therapy skin dose

Yellow and Infrared Low Level Light to Prevent Thyroidectomy Scar Formation

Journal:

Prevention of Thyroidectomy Scars in Asian Adults With Low-Level Light Therapy

Wavelength:
590, 830
Irradiance:
Condition:
Scar
Outcome:

Researchers treated 35 thyroidectomy patients with a combination of 830 nm and 590 nm LED light. Patients received 60 J/cm over a period of 11 minutes for 7 days, starting on the day of surgery. After the first week, they received treatment 3x/week for 3 more weeks. At 3 months, scars on treated patients were lighter and had less color compared to controls. Self-assessment of scar was not significantly different between treated and control groups.

Science study Red light therapy skin dose

Decrease Wrinkles, Increase Collagen 830 nm and 633 nm Comparison

Journal:

A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings

Wavelength:
633, 830
Irradiance:
Condition:
Collagen, Rejuvenation, Wrinkles, Aging Skin
Outcome:

76 patients received split face LED treatment with 830 nm, 633 nm, or a combination of 830 nm and 633 nm. The control group received a sham treatment. Patients received therapy twice a week for four weeks. Measuring skin elasticity and melanin revealed wrinkle reduction as high as 36% and up to 19% skin elacity increase. Researchers concluded that 830 and 633nm alone and in combination are effective wrinkle reducing wavelengths.

Science study Red light therapy skin dose

White (411-777) and Red (660 nm) Reduction of Wrinkles Over 12 Weeks

Journal:

The Efficacy and Safety of 660 nm and 411 to 777 nm Light-Emitting Devices for Treating Wrinkles

Wavelength:
660, Range, 411, 777
Irradiance:
Condition:
Wrinkles, Aging Skin
Outcome:

Researchers treated subjects with LED therapy the specific wavelength 660 nm (red for group 1) and a range of wavelengths from 411 to 777 nm (white for group 2). 52 women received 5.17 J daily for 12 weeks. Wrinkles significantly improved (reduced). Group 1 had slightly better results, but the differences were not significant.

Science study Red light therapy skin dose

Non-UV 420 nm and 453 nm Blue Light Psoriasis Regimen

Journal:

Prospective randomized study on the efficacy of blue light in the treatment of psoriasis vulgaris

Wavelength:
420, 453
Irradiance:
Condition:
Psoriasis
Outcome:

Forty patients self-treated with 420 nm blue LED light therapy once a day for four weeks. 20 patients self-treated with 453 nm blue LED in parallel. Both groups should statistically substantial improvement at 4 weeks. Gains reversed when treatment stopped.

Science study Red light therapy skin dose

453 nm Blue Light LED Therapy Psoriasis Regimen

Journal:

Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Wavelength:
453
Irradiance:
200 group 1, 100 group 2
Condition:
Psoriasis
Outcome:

47 patients with mild psoriasis received 200 mW/cm^2 (group 1) or 100 mW/cm^2) group 2 UV-free blue LED treatment over 12 weeks. Patients reported high satisfaction with the results, which were statistically significant as well.

Science study Red light therapy skin dose

633 nm and 830 nm Psoriasis LED Therapy Regimen

Journal:

Combination 830-nm and 633-nm light-emitting diode phototherapy shows promise in the treatment of recalcitrant psoriasis: preliminary findings

Wavelength:
633, 830
Irradiance:
Condition:
Psoriasis
Outcome:

Nine psoriasis patients used 633 nm red and 830 nm infrared LED therapy on recalcitrant psoriasis. The majority had failed earlier treatments. Seven patients show 60% to 100% clearance of psoriasis symptoms when measured from three to 8 months after treatment. Two of the subjects could not be located.

Science study Red light therapy skin dose

Physician’s Office Psoralen UVA and UVB for Psoriasis

Journal:

Psoralen-ultraviolet A treatment with Psoralen-ultraviolet B therapy in the treatment of psoriasis

Wavelength:
Range
Irradiance:
Condition:
Psoriasis
Outcome:

Researchers treated 25 psoriasis patients with psoralen and ultraviolet-A (PUVA), and another 25 patients with psoralent and ultraviolet-B (PUVB). Psoriasis affected 25-70% of the patient’s skin. After 8 weeks of treatment, 92% of the PUVA group, and 80% of the PUVB group had remission. Limbs and trunk were more resistant than the rest of the body. 28% of PUVA and 24% of PUVB suffered erythema (redness); 32% and 28% pruitis (itchiness); 28% and 24% nausea and vomiting; 16% and 12% fever & malaise; 12% and 16% headache; 1% and 0% blister; 1% and 0% claustrophobia. Researchers concluded that PUVA and PUVB had substantially similar positive outcomes.

Science study Red light therapy skin dose

Narrow Band Ultraviolet B (NB-UVB) Psoriasis Treatment (Not a Home Treatment)

Journal:

Ultraviolet B Phototherapy for Psoriasis: Review of Practical Guidelines

Wavelength:
308
Irradiance:
Condition:
Psoriasis
Outcome:

Physician’s office treatment (not a home therapy) using Narrow Band Ultraviolet B (NB-UVB) for psoriasis patients affected on greater than 10% of the body and have not responded to other treatments. UVB is dangerous without safety precautions. The doctor uses an excimer laser. The patient is treated 2x-3x per week. Is potentially combined with “emollients, calcipotriene, cortico-steroids, retinoids, and tar. NB-UVB can be used in selected patients with traditional systemic agents such as methotrexate, mycophenolate mofetil, and cyclosporine…”

Science study Red light therapy skin dose

Thyroid Safety Using LED Therapy on Neck

Journal:

The Use of a Light-Emitting Diode Device for Neck Rejuvenation and Its Safety on Thyroid Glands

Wavelength:
630, 850
Irradiance:
25 (12.5 per color)
Condition:
Collagen, Wrinkles, Aging Skin
Outcome:

30 women with no history of thyroid disease received 16 weeks of daily LED treatment in the neck area. Followup showed neck wrinkle reduction and no changes to the thyroid. This study includes only healthy participants. It does not test thyroid safety for subjects with a history of: benign thyroid disease, malignant thyroid disease, “keloid scarring, previous inflammatory or infectious skin diseases, uncontrolled medical illness, pregnancy,” or the use of growth factor-related cosmetics.

630 nm, 850 nm, 25 mW/cm2 (12.5 mW/cm^2 per color)

Red light therapy bone dose

Tendonitis in Athletes Red Light Dose

Journal:

830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study

Wavelength:
830
Irradiance:
0.05
Condition:
Tendonitis
Outcome:

830 nm, 0.05 mW/cm^2, 60 J/cm^2, 1200 s relieved tendonitis

EMF Therapy muscle red light dose

One 630 nm Treatment Reduces Muscle Soreness and Reduces Recovery Weakness

Journal:

Light-emitting diode phototherapy improves muscle recovery after a damaging exercise

Wavelength:
630
Irradiance:
100
Condition:
Muscle Soreness
Outcome:
Apply one 630 nm LED photon therapy treatment to post-exercise subject biceps to reduce muscle soreness and increase recovery strength as much as 96 hours after exercise.
Twin leg press exercise

Infrared Reduced Muscle Soreness, Decreases Recovery Time

Journal:

Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins.

Wavelength:
850
Irradiance:
0.2 mW/cm^2
Condition:
Muscle Soreness, Muscle Strength, Pain
Outcome:

Reduce muscle damage, muscle pain (soreness), muscle atrophy, muscle recovery time; increase muscle mass, and athletic performance treating the quadriceps femoris muscles with 850 nm LED light with a total of 75 J.

Green Light Therapy wound healing dose

Mouth Ulcer (Wound) Treatment Green Light Dose

Journal:

Efficacy of low-level laser therapy in treatment of recurrent aphthous ulcers – a sham controlled, split mouth follow up study

Wavelength:
532
Irradiance:
Unknown
Condition:
Wound
Outcome:

Researchers treated 30 canker sore patients with 1 session of green light therapy.

They broke the session into four treatment sections.

The 4-part treatment significantly reduced patients’ pain and lesion size.

Treated subjects healed in 3 days on average. Sham subjects healed in 8 days.

 

Green light therapy fat loss dose

Cellulite Reduction Green Light Dose

Journal:

A double-blind, placebo-controlled randomized trial evaluating the ability of low-level laser therapy to improve the appearance of cellulite

Wavelength:
532
Irradiance:
Unknown
Condition:
Fat
Outcome:

Use green 532 nm diodes without massage or mechanical manipulation to improve the appearance of cellulite in thighs and buttocks.

Researchers treated 34 women with low-energy green light.

Subjects receives three treatments a week for 2 weeks (6).

Researchers treated subjects’ hips, thighs, a waist. Treatments lasted 30 min.

Subjects had significant:

decrease in circumference of treated areas
decrease in baseline body weight
reduction in BMI
reduction in cellulite

Green light therapy fat loss dose

Circumference Reduction in Hips, Thigh and Abdomen Green Light Dose

Journal:

Low-Level Laser Therapy for Reducing the Hip, Waist, and Upper Abdomen Circumference of Individuals with Obesity

Wavelength:
532
Irradiance:
170 mW/cm^2
Condition:
Fat
Outcome:

Use green light therapy to reduce hip, thigh and abdomen circumference. Subject lost an average of 15.21 cm circumference after 12 sessions of low dose green light.

red light therapy for hair growth dose

Infrared Plus Minoxidil Superior to Minoxidil Alone at Growing Hair

Journal:

The effectiveness of adding low-level light therapy to minoxidil 5% solution in the treatment of patients with androgenetic alopecia

Wavelength:
785
Irradiance:
10-50 mW/cm^2
Condition:
Hair Growth
Outcome:

Researchers tested 785 nm (infrared) light on balding patients aged 17 to 45 years old.

The treated group received 5% minoxidil solution and infrared light therapy two times per day.

The control group received 5% minoxidil and a sham LED treatment device.

Researchers tested hair patient satisfaction,  hair density and hair growth.

At 12 months, the patients getting both minoxidil and LED ligh therapy were singificantly happier with their hair growth than the sham group.

red light therapy for hair growth dose

Increase Hair Coverage with 660 nm Red LED Light

Journal:

Efficacy and Safety of a Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial

Wavelength:
650, 660
Irradiance:
Unknown
Condition:
Hair Growth
Outcome:

Researchers applied 660 nm LED light to balding men and women over a 24 week study.

The light therapy significantly increased the hair’s coverage area.

More of the subject’s heads had hair at 24 weeks than at the beginning of the study.

The sham group saw no hair gains.

Researchers also used 650 nm red laser light, and got the same results.

 

red light therapy for hair growth dose

Helmet LED Treatment Grows Hair

Journal:

The Effectiveness of Combination Therapies for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

Wavelength:
655
Irradiance:
Condition:
Hair Growth
Outcome:

Researchers treated balding men and women aged 19 to 65 years old with 655 nm red light therapy (LLLT: low level light therapy).

They fitted helmets with 2.36 mW LED 655 nm output to administer the treatment.

They tested hair growth at 0, 8 and 16 weeks.

At the end of 16 weeks, particpants in the treatment group had more hairs and they were thicker as well.

The control group did not experience an increase in hair quanity or thickness.

There were no adverse side effects.

 

red light therapy for hair growth dose

Hair Regrowth and Lichen Planopilaris Symptom Reduction

Journal:

Effectiveness Of Low-Level Laser Therapy In Lichen Planopilaris

Wavelength:
650, 660
Irradiance:
unknown
Condition:
Hair Growth
Outcome:

Researchers treated patients to low level light therapy (LLLT) using red light with a  630 nm wavelength.

All treated patients had lichen planopilaris.

Symptoms included redness (erythema), corkscrew hairs indicating too much keratin production (perifollicular hyperkeratosis), and hair loss.

After 3 and 6 months, the patients had more and thicker hair.

After 3 months, the erythema and perifollicular hyperkeratosis settled down, but after 6 months it had returned.

 

red light therapy for hair growth dose

Four Successful Lichen Planopilaris Red Light Cases

Journal:

Lichen Planopilaris and Low-Level Light Therapy: Four Case Reports and Review of the Literature About Low-Level Light Therapy and Lichenoid Dermatosis.

Wavelength:
650, 660
Irradiance:
unknown
Condition:
Hair Growth
Outcome:

Researchers reviewed four cases using red light to treat licehn planopilaris (LPP).

Using 650 nm or 660 nm light scientists reversed inflammation, LPP symptoms, and regrew natural hair.

They wrote that the patients showed “a dramatic response to LLLT [red light therapy].”

Patients experienced no adverse side effects.

Science study Red light therapy skin dose

Acne Reduction Green Light Dose

Journal:

Low-fluence 585 nm Q-switched Nd:YAG laser: a novel laser treatment for post-acne erythema

Wavelength:
585
Irradiance:
Condition:
Acne
Outcome:

Green light reduced acne lesions by 67% when measured at 6 weeks past the end of the study.

Red Light Therapy circulation dose

Waist Reduction Body Contour Red Light Dose

Journal:

Efficacy of Low-Level Laser Therapy for Body Contouring and Spot Fat Reduction

Wavelength:
Range
Irradiance:
Unknown
Condition:
Fat
Outcome:

635-680 nm red light of unknown dose reduced girth at waist by 2.15 cmin men and women over 4 weeks of treatment.

 

Red Light Therapy circulation dose

Increase Lymphatic Activity Blue, Red, and Infrared Light Dose

Journal:

Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring

Wavelength:
420, Range
Irradiance:
Unknown
Condition:
Acne, Collagen, Rejuvenation, Wrinkles, Hyperpigmentation, Aging Skin
Outcome:

Increase lymphatic system activity correlated:

  • reduced wrinkles
  • reduced hyperpigmentation
  • enhanced rejuvenation (glow)
  • increased collagen
  • decreased acne
Science study Red light therapy skin dose

Acne Blue and Red Light Dose

Journal:

Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV

Wavelength:
633, 415
Irradiance:
Condition:
Acne
Outcome:

Blue and red LED light treatments reduced inflammatory acne by 34% and non inflammatory acne by 78%. In addition, melanin decreased significantly, tone brightened, and texture improved.

Science study Red light therapy skin dose

Acne Portable LED Red Light Dose

Journal:

Red light phototherapy alone is effective for acne vulgaris: randomized, single-blinded clinical trial

Wavelength:
635, 670
Irradiance:
6 mW/area
Condition:
Acne
Outcome:

Treatment of acne vulgaris with a portable 630 nm to 670 nm portable LED device resulted in reduced inflammatory and non-inflammatory acne lesion counts.

Science study Red light therapy skin dose

Acne Handheld Device Blue and Red Dose

Journal:

Handheld LED array device in the treatment of acne vulgaris

Wavelength:
633, 415
Irradiance:
Unknown
Condition:
Acne
Outcome:

415 combined with 633, 21 subjects, self administered handheld device over 4 weeks. Reduced lesion counts throughout study and 8 weeks post therapy, 69% reduction at 8 weeks

Science study Red light therapy skin dose

Acne Vulgaris in Women Red Light Dose

Journal:

Non-invasive diagnostic evaluation of phototherapeutic effects of red light phototherapy of acne vulgaris

Wavelength:
Range
Irradiance:
Unknown
Condition:
Acne
Outcome:

Decreased acne lesions, decreased skin sebum excretion in women at end of treatment and 3 month followup. Study used multiple wavelengths in the red range.

Science study Red light therapy skin dose

Acne Vulgaris Alternating Red and Blue Light Dose

Journal:

A study to determine the effect of combination blue (415 nm) and near-infrared (830 nm) light-emitting diode (LED) therapy for moderate acne vulgaris

Wavelength:
830, 415
Irradiance:
Unknown
Condition:
Acne
Outcome:

Alternating 415 nm and 830 nm at each session reduced inflammatory acne lesions up to 83.3%. Non inflammatory lesions improved an average of 48.8%, but four patients had an increase. There were no side effects.

Science study Red light therapy skin dose

Acne Red but Not Infrared Light Therapy Dose

Journal:

Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris

Wavelength:
630, 890
Irradiance:
Unknown
Condition:
Acne
Outcome:

10 weeks after last treatment, group treated with 630 nm light had significant reduction in moderate acne. The 890 nm group did not have a significant reduction.

 

Science study Red light therapy skin dose

Korean Acne Reduction Using Home Red and Blue Light Dose

Journal:

The clinical and histological effect of home‐use, combination blue–red LED phototherapy for mild‐to‐moderate acne vulgaris in Korean patients: a double‐blind, randomized controlled trial

Wavelength:
660, 420
Irradiance:
Unknown
Condition:
Acne
Outcome:

Red and blue light two to five minute sessions for four weeks resulte in:

  • inflammatory acne lesions reduced by 77%n
  • oninflammatory acne lesions decreased by 54%
  • reduced sebum output
  • reduced inflammatory markers
  • decreased sebaceous gland size
  • no side effects

Home consumer red and blue LED device reduced acne lesions, sebum output, inflammatory markers and sebaceous gland size in Korean patients, with no side effects.

Science study Red light therapy skin dose

Chinese Patient Acne Reduction Blue and Red Light Dose

Journal:

Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients

Wavelength:
420
Irradiance:
Unknown
Condition:
Acne
Outcome:

90% or greater acne reduction at one month using blue LED therapy on the face of Chinese patients. Some redness after treatment resolving in 2h. After 3 months, 12 of 22 patients had minimal papules and pustules, “but no nodular pustules recurred.”

Science study Red light therapy skin dose

Teenage Acne Reduction Blue and Red Light Dose

Journal:

Clinical comparison of salicylic acid peel and LED-Laser phototherapy for the treatment of Acne vulgaris in teenagers.

Wavelength:
660, 470
Irradiance:
Unknown
Condition:
Acne
Outcome:

Blue and red light facial and back therapy immediately improved acne symptom better than salicylic acid treatment . “The number of comedones, papules and pustules decreased significantly at the end of the session.”

Red Light Therapy circulation dose

Possible Cholesterol and Triglyceride Reduction Red Light Dose

Journal:

Reduction in Cholesterol and Triglyceride Serum Levels Following Low-Level Laser Irradiation: A Noncontrolled, Nonrandomized Pilot Study

Wavelength:
635
Irradiance:
85 mW/area
Condition:
Cholesterol
Outcome:

Use 635 nm light to reduced triglyceride and cholesterol levels.

Green light therapy fat and weight doses

Arm Circumference Reduction Red Light Dose

Journal:

Effect of 635nm Low-level Laser Therapy on Upper Arm Circumference Reduction

Wavelength:
635
Irradiance:
85
Condition:
Fat
Outcome:

Use 635 nm red light to reduce upper arm circumference more than 1.5 cm.

Red light therapy pain decrease dose

Breast Augmentation Post Operative Pain Reduction Red Light Dose

Journal:

Low-Level Laser Therapy Effectiveness for Reducing Pain after Breast Augmentation

Wavelength:
635
Irradiance:
14
Condition:
Pain
Outcome:

Reduce surgical pain by 37%.

Red light therapy eye sight dose

Age-Related Macular Degeneration Red Light Dose

Journal:

Low-level laser therapy improves vision in patients with age-related macular degeneration

Wavelength:
780
Irradiance:
7.5
Condition:
Macular Degeneration
Outcome:

Improve visual acuity in cataract and healthy eyes; reduce metamophosia, scotoma, and dyschromatopsia; reduced wet AMD edma and bleeding; for at least 3-6 mo. post treatment.

Green light therapy fat and weight doses

Liposuction Fat Emulsification Red Light Dose

Journal:

Low-Level Laser-Assisted Liposuction: A 2004 Clinical Study of its Effectiveness for Enhancing Ease of Liposuction Procedures and Facilitating the Recovery Process for Patients Undergoing Thigh, Hip, and Stomach Contouring

Wavelength:
635
Irradiance:
28 mW
Condition:
Fat
Outcome:

Emulsify fat before liposuction extraction.

Green light therapy fat and weight doses

Fat Contour and Melting Near and Medium Infrared Light Dose

Journal:

Efficacy and safety of long pulse 1064 and 2940 nm lasers in noninvasive lipolysis and skin tightening

Wavelength:
1064, 2940
Irradiance:
Condition:
Fat
Outcome:

Reduce waist circumference and total body fat, decreased fat thickness, and improve skin stiffness.

Green light therapy fat and weight doses

Hunger Hormone Blue, Green, and Red Light Dose

Journal:

Light Modulates Leptin and Ghrelin in Sleep-Restricted Adults

Wavelength:
475, 532, 633
Irradiance:
.000325/cm^2
Condition:
Sleep
Outcome:

Reduce sleep-deprivation hunger using red light to increase leptin and reduce ghrelin.

Red light therapy brain dose

Improve Muscle and Pain in Spastic Muscle Stroke Limbs Red Light Dose

Journal:

Effects of low-level laser therapy (LLLT 808 nm) on lower limb spastic muscle activity in chronic stroke patients

Wavelength:
808
Irradiance:
unknown but beam spot area is 0.0314 cm^2
Condition:
Stroke, Exercise, Muscle Soreness, Muscle Strength
Outcome:

Use 808 nm on weak leg of stroke patient with muscle spacicity to decrease pain, increase time to muscle fatigue onset, and increase peak torque.

Red light exercise dose

Decreased Post Exercise Recovery Time Red Light Dose

Journal:

Assessing the Therapeutic Effect of 630 nm Light-Emitting Diodes Irradiation on the Recovery of Exercise-Induced Hand Muscle Fatigue with Surface Electromyogram

Wavelength:
630
Irradiance:
0.048
Condition:
Exercise, Muscle Soreness, Muscle Strength
Outcome:

Decrease muscle fatigue using 630 nm LED irradiation.

Science study Red light therapy skin dose

Beauty Angel Orange, Yellow, and Red Light Dose

Journal:

A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase

Wavelength:
Range
Irradiance:
see more info
Condition:
Collagen, Rejuvenation, Wrinkles, Aging Skin
Outcome:

Reduce wrinkles, increase collagen

Red light therapy eye sight dose

Blue Sight Improvement in Aging Eyes Red Light Dose

Journal:

Optically improved mitochondrial function redeems aged human visual decline

Wavelength:
670
Irradiance:
40
Condition:
Eyesight
Outcome:

Improve blue contrast vision in adults over 40 years old.

Science study Red light therapy skin dose

Increase Collagen Red Light Dose

Journal:

Regulation of Skin Collagen Metabolism In Vitro Using a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single-Blinded Study

Wavelength:
660
Irradiance:
50
Condition:
Collagen, Wrinkles, Aging Skin
Outcome:

Reverse collagen downregulation and MMP-1 upregulation, decreasing wrinkles, and increasing collagen.

Red light therapy brain dose

Traumatic Brain Injury Lesion Red Light Dose

Journal:

Transcranial Photobiomodulation Therapy in the Cognitive Rehabilitation of Patients with Cranioencephalic Trauma

Wavelength:
630
Irradiance:
25.73
Condition:
Cognition, Depression, Emotion, Sleep, Traumatic Brain Injury, Headache, PTSD
Outcome:

Improvements in immediate recall, information processing speed, verbal learning, PTSD stress reduction, depression reduction, reduced headache, improved sleep, and many more benefits.

Red light therapy brain dose

Keto Diet and Alzheimer’s Red Light Dose

Journal:

Nutritional Ketosis and photobiomodulation remediate mitochondria warding off Alzheimer’s disease in a diabetic, ApoE4+ patient with mild cognitive impairment: A case report

Wavelength:
810
Irradiance:
Unknown
Condition:
Cognition, Diabetes
Outcome:

Ketogenic diet and PBM restore cognition, increase insulin sensitivity, improve metabolic flexibilityin diabetic, ApoE4 heterozygous individual.

Red light therapy brain dose

Alzheimer’s Vielight 810 nm Red Light Dose

Journal:

Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients With Dementia: A Pilot Trial

Wavelength:
810
Irradiance:
Intransal irradiance week 1, 14.2 mW/cm^2; week 2: 23 mW/cm^2; transcranial irradiance week 2: 41 mW/cm^2
Condition:
Cognition, Dementia/Alzheimers
Outcome:

Intranasal and transcranial application of 810 nm improved memory, cognition and MRI results in Alzheimer’s patients.

Red light therapy brain dose

Reverse Cognitive Decline Red Light Dose

Journal:

Rapid Reversal of Cognitive Decline, Olfactory Dysfunction, and Quality of Life Using Multi-Modality Photobiomodulation Therapy: Case Report.

Wavelength:
635, 810
Irradiance:
Unknown
Condition:
Cognition, Dementia/Alzheimers
Outcome:

Alzheimer’s patient treatment: Improve cognitive and memory scores; regain sense of smell; reduce stress in patient and caregiver.

Red light therapy bone dose

Facial Fracture Edema Red Light Dose

Journal:

The Effect of Light-Emitting Diode (590/830 Nm)-Based Low-Level Laser Therapy on Posttraumatic Edema of Facial Bone Fracture Patients

Wavelength:
590, 830
Irradiance:
Unknown
Condition:
Bone Fracture, Pain
Outcome:

16.5% edema reduction in LLLT group compared to 7.3% in sham group.

Red light exercise dose

Pre-Exercise Bicep Recovery Red Light Dose

Journal:

Effects of Low-Level Laser Therapy (LLLT) in the Development of Exercise-Induced Skeletal Muscle Fatigue and Changes in Biochemical Markers Related to Postexercise Recovery

Wavelength:
810
Irradiance:
Power is 200 mW, irradiance is unknown
Condition:
Exercise, Muscle Soreness, Muscle Strength
Outcome:

Increase voluntary elbow flexion repetitions before exhaustion.

Red light therapy bone dose

Male Osteopenia Red Light Dose

Journal:

Efficacy of High Intensity Laser Therapy in the Treatment of Male With Osteopenia or Osteoporosis: A Randomized Placebo-Controlled Trial

Wavelength:
1064
Irradiance:
0.2
Condition:
Osteopenia
Outcome:

Decrease pain and fall risk in men with osteopenia.

Red light therapy bone dose

Closed Bone Fracture Red Light Dose

Journal:

Therapeutic Outcomes of Low-Level Laser Therapy for Closed Bone Fracture in the Human Wrist and Hand

Wavelength:
830
Irradiance:
60
Condition:
Bone Fracture
Outcome:

Reduce pain and improve healing of wrist and hand closed bone fractures.

Red light therapy brain dose

Traumatic Brain Injury Red Light Dose

Journal:

Improved Cognitive Function After Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports

Wavelength:
633, 870
Irradiance:
22.2 mW/cm^2
Condition:
Cognition, Traumatic Brain Injury
Outcome:

Improve cognition and memory in chronic TBI patients.

Green light therapy fat and weight doses

Fat Liquifaction 80% and 99% Red Light Doses

Journal:

Fat Liquefaction: Effect of Low-Level Laser Energy on Adipose Tissue

Wavelength:
635
Irradiance:
10
Condition:
Fat
Outcome:

Release fat from fat cell.

Arthritis red light therapy dose

Osteoarthritis Neck Pain Reduction Infrared Light Dose

Journal:

The clinical efficacy of low-power laser therapy on pain and function in cervical osteoarthritis.

Wavelength:
Range
Irradiance:
50
Condition:
Arthritis
Outcome:

Reduce neck osteoarthritis pain.

Red light therapy pain decrease dose

Frozen Shoulder Pain Reduction Red Light Dose

Journal:

Low-power laser treatment in patients with frozen shoulder: preliminary results.

Wavelength:
810
Irradiance:
infer 100
Condition:
Frozen Shoulder
Outcome:

Decrease frozen shoulder pain.

Science study red light therapy motor function

TMJ Improved Movement and Pain Infrared Light Dose

Journal:

Lasertherapy efficacy in temporomandibular disorders: control study.

Wavelength:
Range
Irradiance:
40
Condition:
Pain, TMJ
Outcome:

Decrease TMJ pain and increase jaw movement.

Science study red light therapy motor function

TMJ Pain, Chewing Improvements Infrared Light Dose

Journal:

Evaluation of low-level laser therapy in the treatment of temporomandibular disorders.

Wavelength:
Range
Irradiance:
43.21
Condition:
Pain, TMJ
Outcome:

Improve TMJ mouth opening range, decrease pain, chewing difficulty, and tenderness.

Arthritis red light therapy dose

Pain, Flexion, Circumference Knee Osteoarthritis Red Light Dose

Journal:

The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial.

Wavelength:
830
Irradiance:
10,000
Condition:
Arthritis, Pain
Outcome:

Improve knee osteoarthritis pain, flexion, pressure, sensitivity, and circumference.

Arthritis red light therapy dose

Painful Knee Osteoarthritis Infrared Light Dose

Journal:

Efficacy of different therapy regimes of low‐power laser in painful osteoarthritis of the knee: A double‐blind and randomized‐controlled trial

Wavelength:
Range
Irradiance:
10
Condition:
Arthritis, Pain
Outcome:

Reduce knee osteoarthritis pain.

Arthritis red light therapy dose

Geriatric Degenerative Osteoarthritis Red Light Dose

Journal:

Improvement of Pain and Disability in Elderly Patients with Degenerative Osteoarthritis of the Knee Treated with Narrow‐Band Light Therapy

Wavelength:
633, 830
Irradiance:
830 nm 11 power density C, 122 power density P; 633 nm 8 power density C, 34 power density P
Condition:
Arthritis, Pain
Outcome:

Reduce geriatric degenerative osteoarthritis pain.

Green light therapy fat and weight doses

Thigh Fat Reduction Red Light Dose

Journal:

Reduction of Subcutaneous Fat and Improvement in Cellulite Appearance by Dual-Wavelength, Low-Level Laser Energy Combined With Vacuum and Massage

Wavelength:
650, 915
Irradiance:
unknown
Condition:
Fat
Outcome:

Reduce thigh fat and circumference.

red light therapy for hair growth dose

Hair Growth in Women Red Light Dose

Journal:

The Growth of Human Scalp Hair in Females Using Visible Red Light Laser and LED Sources

Wavelength:
655
Irradiance:
255
Condition:
Hair Growth
Outcome:

Increase female scalp hair count.

Science study Red light therapy skin dose

Reduced Rosacea Red Light Dose

Journal:

Is light-emitting diode phototherapy (LED-LLLT) really effective?

Wavelength:
830
Irradiance:
50
Condition:
Rosacea
Outcome:

Elimnate rosacea small acneiform papules and decrease redness.

Science study Red light therapy skin dose

Reduced Facial Contact Dermatitis Red Light Dose

Journal:

Is light-emitting diode phototherapy (LED-LLLT) really effective?

Wavelength:
830
Irradiance:
50
Condition:
Dermatitis
Outcome:

Reduce facial contact dermatitis.

Arthritis red light therapy dose

Knee Arthritis Pain and Inflammation Reduction Red Light Dose

Journal:

Photobiomodulation via a Cluster Device Associated With a Physical Exercise Program in the Level of Pain and Muscle Strength in Middle-Aged and Older Women With Knee Osteoarthritis: A Randomized Placebo-Controlled Trial

Wavelength:
808
Irradiance:
100
Condition:
Arthritis, Pain
Outcome:

Reduce knee arthritis pain and inflammation.

Arthritis red light therapy dose

Knee Osteoarthritis Pain Reduction Red Light Dose

Journal:

Incorporation of Photobiomodulation Therapy Into a Therapeutic Exercise Program for Knee Osteoarthritis: A Placebo-Controlled, Randomized, Clinical Trial

Wavelength:
640, 875, 905
Irradiance:
100
Condition:
Arthritis, Pain
Outcome:

Reduce knee osteoarthritis pain.

Arthritis red light therapy dose

Prevent Arthritis Joint Degeneration Red Light Dose

Journal:

Can Photobiomodulation Associated With Implantation of Mesenchymal Adipose-Derived Stem Cells Attenuate the Expression of MMPs and Decrease Degradation of Type II Collagen in an Experimental Model of Osteoarthritis?

Wavelength:
808
Irradiance:
50
Condition:
Arthritis, Pain
Outcome:

Prevent knee arthritis inflammation and degeneration.

Science study Red light therapy skin dose

Dissecting Cellulitis Reduction Red Light Dose

Journal:

Is light-emitting diode phototherapy (LED-LLLT) really effective?

Wavelength:
830
Irradiance:
50
Condition:
Cellulitis
Outcome:

Reduce dissecting cellulitis inflammation.

Science study red light therapy motor function

Expected Post Exercise Stress Markers Reduction Red and Infrared Dose

Journal:

Comparison between cold water immersion therapy (CWIT) and light emitting diode therapy (LEDT) in short-term skeletal muscle recovery after high-intensity exercise in athletes—preliminary results

Wavelength:
660, 850
Irradiance:
10, 30
Condition:
Exercise
Outcome:

Reduce post-exercise lactate and creatine kinase, known to be consistent with faster exercise recovery.

Science study red light therapy motor function

Speedier Knee Exercise Recovery Red and Infrared Dose

Journal:

Effect of Light-Emitting Diodes Therapy (LEDT) on Knee Extensor Muscle Fatigue

Wavelength:
660, 850
Irradiance:
10, 30
Condition:
Arthritis, Pain
Outcome:

Reduce post-exercise loss of function.

Red light therapy pain decrease dose

Achilles Tendonitis Inflammation Red Light Dose

Journal:

A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations

Wavelength:
904
Irradiance:
20
Condition:
Tendonitis
Outcome:

Reduce Achilles tendinitis pain and inflammation.

Red light therapy pain decrease dose

Epicondylitis (Chronic Tendinopathy, Tendonitis) Relief Red Light Dose

Journal:

The Effectiveness of Therapeutic Class IV (10 W) Laser Treatment for Epicondylitis

Wavelength:
810, 980
Irradiance:
10,000
Condition:
Tendonitis
Outcome:

Improve tendonitis functionality, increase strength, decrease pain, and improve extension in tendinitis

Red light therapy virus dose: herpes, shingles, post herpetic neuralgia

Herpes Zoster Pain Remission Red Light Dose

Journal:

TREATMENT OF POST HERPETIC NEURALGIA USING A 904 nm (INFRARED) LOW INCIDENT ENERGY LASER: A CLINICAL STUDY

Wavelength:
904
Irradiance:
6
Condition:
Herpes/Shingles/Post Herpetic Neuralgia, Pain
Outcome:

Reduce post-herpetic neuralgia pain from from 8.54/10 to 0-3/10.

Red light therapy virus dose: herpes, shingles, post herpetic neuralgia

Reduce Herpes Zoster Pain Red Light Dose

Journal:

Early Application of Low-Level Laser May Reduce the Incidence of Postherpetic Neuralgia (PHN)

Wavelength:
633
Irradiance:
50
Condition:
Herpes/Shingles/Post Herpetic Neuralgia, Pain
Outcome:

Prevent post-herpetic neuralgia: “Applying LLLT within the first 5 days of herpes zoster eruption significantly reduced the incidence of PHN.”

LLLT: low level light therapy

PHN: post-herpetic neuralgia

Red light therapy virus dose: herpes, shingles, post herpetic neuralgia

Pain Reduction of Post-Herpetic Neuralgia Red Light Dose

Journal:

Role of Low-Level Laser Therapy in Post-Herpetic Neuralgia: A Pilot Study

Wavelength:
650
Irradiance:
60 (theoretical)
Condition:
Herpes/Shingles/Post Herpetic Neuralgia, Pain
Outcome:

Reduce shingles pain from severe to severe/moderate/mild with no remissions for at least “several months.”

Red light therapy virus dose: herpes, shingles, post herpetic neuralgia

Prevent Herpes Recurrence Red Light Dose

Journal:

Low-intensity Laser Therapy Is an Effective Treatment for Recurrent Herpes Simplex Infection. Results From a Randomized Double-Blind Placebo-Controlled Study

Wavelength:
690
Irradiance:
80
Condition:
Herpes/Shingles/Post Herpetic Neuralgia, Pain
Outcome:

Increase time to recurrence of herpes outbreak.

Red light therapy virus dose: herpes, shingles, post herpetic neuralgia

Herpes Symptom Reduction Red Light Dose

Journal:

Effect of Laser Phototherapy on Recurring Herpes Labialis Prevention: An in Vivo Study

Wavelength:
780
Irradiance:
60
Condition:
Herpes/Shingles/Post Herpetic Neuralgia
Outcome:

780 nm, 60 mW, 3 J/cm^2 (50 s) or 4.5 J/cm^2 (75 s), 2x/week/10 weeks (20) reduced herpes pain and lesion size.

Red light therapy virus dose: herpes, shingles, post herpetic neuralgia

Herpes Treatment Red Light Dose

Journal:

Recurrent Herpes Simplex Infections: Laser Therapy as a Potential Tool for Long-Term Successful Treatment

Wavelength:
660
Irradiance:
100
Condition:
Herpes/Shingles/Post Herpetic Neuralgia
Outcome:

660 nm, 100 mW, 8 s, 12 points/5 sessions (60 applications) per point , 30 J/cm^2 encouraged herpes remission for at least 17 months.

Red light therapy virus dose: herpes, shingles, post herpetic neuralgia

Herpes Simplex Red Light Dose

Journal:

The Effect of 670-nm Low Laser Therapy on Herpes Simplex Type 1

Wavelength:
670
Irradiance:
40
Condition:
Herpes/Shingles/Post Herpetic Neuralgia
Outcome:

Reduce outbreak length and increase time between herpes outbreaks.

Green light therapy fat and weight doses

Acupuncture Weight Loss Red Light Dose

Journal:

Laser Acupuncture Reduces Body Fat in Obese Female Undergraduate Students

Wavelength:
810
Irradiance:
250
Condition:
Fat
Outcome:

Reduce body mass index, body fat mass, waist girth, hip girth, and wast to hip ratio.

Red Light Therapy circulation dose

Increased Blood Flow in Meningomyelocele Red Light Dose

Journal:

Impact of Low Level Laser Therapy on Skin Blood Flow

Wavelength:
680
Irradiance:
60
Condition:
Circulation,
Outcome:

Increase skin blood flow.

Red Light Therapy circulation dose

Increased Nitric Oxide and Blood Flow Red Light Dose

Journal:

Low-level Laser Treatment With Near-Infrared Light Increases Venous Nitric Oxide Levels Acutely: A Single-Blind, Randomized Clinical Trial of Efficacy

Wavelength:
890
Irradiance:
636
Condition:
Circulation
Outcome:

890 nm, 636 mW/cm^2, 60 s, 300s, 900 s, increased blood nitric oxide

Red Light Therapy circulation dose

Total Cholesterol Reduction Red Light Dose

Journal:

Randomized, Double-Blind, and Placebo-Controlled Clinic Report of Intranasal Low-Intensity Laser Therapy on Vascular Diseases

Wavelength:
650
Irradiance:
8.38
Condition:
Cholesterol
Outcome:

Lower total cholesterol and increase HDL-c.

Red light therapy wound dose

Improved Microcirculation Wound Healing, Reduced Pain Red Light Dose

Journal:

Effects of 780 Nm Diode Laser Irradiation on Blood Microcirculation: Preliminary Findings on Time-Dependent T1-weighted Contrast-Enhanced Magnetic Resonance Imaging (MRI)

Wavelength:
780
Irradiance:
100
Condition:
Wound
Outcome:

Reduce wound pain and increase blood flow.

Red Light Therapy circulation dose

Improve Microcirculation Red Light Dose

Journal:

Immediate Effects of Monochromatic Infrared Energy on Microcirculation in Healthy Subjects

Wavelength:
890
Irradiance:
12
Condition:
Circulation, Diabetes, Wound
Outcome:

Increase capillary blood cell velosity and superficial skin blood flow.

Red light therapy wound dose

Faster Diabetic Wound Healing Red Light Dose

Journal:

The Effect of LED on Blood Microcirculation During Chronic Wound Healing in Diabetic and Non-Diabetic Patients-A Prospective, Double-Blind Randomized Study

Wavelength:
625, 660, 680
Irradiance:
100
Condition:
Diabetes, Wound
Outcome:

Heal chronic wounds in both diabetics and non-diabetics.

Red Light Therapy circulation dose

Reduced Hypertension Red Light Dose

Journal:

Blood Pressure Controlled by Low Reactive Level Diode Laser Therapy (LLLT)

Wavelength:
830
Irradiance:
60
Condition:
Hypertension
Outcome:

Significant reduction in hypertension to healthy measurements in some cases.

Red Light Therapy circulation dose

Increased Brain Blood Flow Red Light Dose

Journal:

The Effects of Transcranial LED Therapy (TCLT) on Cerebral Blood Flow in the Elderly Women

Wavelength:
627
Irradiance:
70
Condition:
Cognition, Dementia/Alzheimers, Traumatic Brain Injury
Outcome:

Increase cerebral artery blood floow, decrease resistance.

Science study red light therapy motor function

Carpal Tunnel with Rheumatoid Arthritis Red Light Dose

Journal:

Effect of Low Level Laser Therapy in Rheumatoid Arthritis Patients With Carpal Tunnel Syndrome

Wavelength:
780
Irradiance:
50
Condition:
Arthritis, Carpal Tunnel, Tendonitis
Outcome:

Decrease wrist pain and increase wrist functionality in carpal tunnel patients who have rheumatoid arthritis.

Science study red light therapy motor function

Carpal Tunnel with Splinting Red Light Therapy Dose

Journal:

The Effectiveness of Conservative Treatments of Carpal Tunnel Syndrome: Splinting, Ultrasound, and Low-Level Laser Therapies

Wavelength:
904
Irradiance:
2.4
Condition:
Carpal Tunnel, Pain, Tendonitis
Outcome:

Decrease carpal tunnel pain.

Science study red light therapy motor function

Carpal Tunnel with Splint Red Light Dose

Journal:

Comparison of Splinting and Splinting Plus Low-Level Laser Therapy in Idiopathic Carpal Tunnel Syndrome

Wavelength:
830
Irradiance:
30
Condition:
Carpal Tunnel, Tendonitis
Outcome:

Increase carpal tunnel strength and mobility.

Science study red light therapy motor function

Carpal Tunnel Function and Pain Improvement Red Light Dose

Journal:

Comparison of the Long-Term Effectiveness of Physiotherapy Programs With Low-Level Laser Therapy and Pulsed Magnetic Field in Patients With Carpal Tunnel Syndrome

Wavelength:
904
Irradiance:
150
Condition:
Carpal Tunnel, Pain, Tendonitis
Outcome:

Decrease carpal tunnel pain.

Science study red light therapy motor function

Carpal Tunnel Pain Reduction Red Light Therapy Dose

Journal:

Placebo-controlled Investigation of Low-Level Laser Therapy to Treat Carpal Tunnel Syndrome

Wavelength:
780
Irradiance:
30
Condition:
Carpal Tunnel, Tendonitis
Outcome:

Reduce carpal tunnel pain, increase meridian nerve conduction in carpal tunnel wrists.

Science study red light therapy motor function

Carpal Tunnel Wrist Splint and Red Light Therapy Dose

Journal:

Low-level Laser Therapy With a Wrist Splint to Treat Carpal Tunnel Syndrome: A Double-Blinded Randomized Controlled Trial

Wavelength:
810
Irradiance:
50
Condition:
Carpal Tunnel, Tendonitis
Outcome:

Increase hand grip strength in carpal tunnel wrists.

Red light therapy brain dose

Stroke Defecit Recovery Red Light Dose

Journal:

A New Treatment Protocol Using Photobiomodulation and Muscle/Bone/Joint Recovery Techniques Having a Dramatic Effect on a Stroke Patient’s Recovery: A New Weapon for Clinicians

Wavelength:
660, 850
Irradiance:
1,400
Condition:
Stroke
Outcome:

Decrease stroke defecits.

N=1 significant stroke symptom improvements in:

  • severe diziness
  • non-functional left hand
  • severe right hand spasticity
  • right lateral sixth nerve palsy
  • unable to walk
Red light therapy brain dose

Achieve Meditative Brainwaves Red Light Dose

Journal:

Effect of Low-Level Laser Stimulation on EEG

Wavelength:
830
Irradiance:
7
Condition:
Addiction
Outcome:

Help substance absuers achieve meditative state.

Red light therapy brain dose

Depression/Suicidal Ideation Red Light Dose

Journal:

Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study

Wavelength:
810, 980
Irradiance:
8000-15000
Condition:
Depression, Emotion
Outcome:

Reduce depression symptoms including sucidal ideation.

Red light therapy brain dose

Low Back Pain and Depression Red Light Dose

Journal:

A Case Control Series for the Effect of Photobiomodulation in Patients With Low Back Pain and Concurrent Depression

Wavelength:
660, 850
Irradiance:
100
Condition:
Depression, Emotion, Pain
Outcome:

Reduce back pain and depression.

Red light therapy brain dose

Depression Symptom Relief Red Light Dose

Journal:

Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial

Wavelength:
823
Irradiance:
36
Condition:
Depression, Emotion
Outcome:

Reduce depression symptoms.

Red light therapy brain dose

Therapy Results Similar to Aerobic Exercise Red Light Dose

Journal:

Cognitive Enhancement by Transcranial Laser Stimulation and Acute Aerobic Exercise

Wavelength:
1064
Irradiance:
250
Condition:
Cognition, Exercise
Outcome:

Improve vigilance task and working memory scores similar to that seen with 20 minutes of aerobic exercise.

Red light therapy brain dose

Better Reaction Time in Concussion Patients Red Light Dose

Journal:

Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures

Wavelength:
903
Irradiance:
16.67
Condition:
Cognition, Dementia/Alzheimers, Traumatic Brain Injury
Outcome:

Decrease physical reaction times in concussion patients.

Red light therapy brain dose

Reduce Cognitive Decline Biomarkers Red Light Dose

Journal:

Beneficial Neurocognitive Effects of Transcranial Laser in Older Adults

Wavelength:
1064
Irradiance:
250
Condition:
Cognition, Dementia/Alzheimers
Outcome:

Improve memory and increase brain blood oxygen in patients at risk for cognitive decline.

Red light therapy brain dose

Enhance Lithium Depression Treatment Red Light Dose

Journal:

Transcranial Photobiomodulation to Augment Lithium in Bipolar-I Disorder

Wavelength:
830
Irradiance:
332
Condition:
Anxiety, Depression, Emotion, Sleep
Outcome:

830 nm, 332 mW/cm^2,120 s, 40 J/cm^2, unknown targets, 8 treatments, unknown schedule, reduced anhedonia apathy, increased libido, decreased anxiety, decreased irritability, decreased impulsivity, improved sleep

Red light therapy brain dose

Traumatic Brain Injury Anxiety and Depression Red Light Dose

Journal:

Psychological Benefits 2 and 4 Weeks After a Single Treatment With Near Infrared Light to the Forehead: A Pilot Study of 10 Patients With Major Depression and Anxiety

Wavelength:
810, 980
Irradiance:
810 nm, 13.2 W/0.89 cm^2, and 810 and 980 nm, 9W/0.89 cm^2
Condition:
Addiction, Alcoholism, Anxiety, Cognition, Depression, Emotion, Traumatic Brain Injury, PTSD
Outcome:

Decrease depression and anxiety in TBI patients.

Red light therapy brain dose

Improved Brain Oxygenation Red Light Dose

Journal:

Transcranial Laser Stimulation Improves Human Cerebral Oxygenation

Wavelength:
1064
Irradiance:
250
Condition:
Cognition, Dementia/Alzheimers, Traumatic Brain Injury
Outcome:

Improve brain oxygen supply.

Science study red light therapy motor function

Decrease Multiple Cerebral Palsy Symptoms Red Light Dose

Journal:

APPLICATION OF LOW REACTIVE-LEVEL LASER THERAPY (LLLT) IN PATIENTS WITH CEREBRAL PALSY OF THE ADULT TENSION ATHETOSIS TYPE

Wavelength:
830
Irradiance:
60
Condition:
Cerebral Palsey
Outcome:

830 nm, 60 mW/cm^2, 30 s/site, 900 s-1800 s total, 1.8 J/cm^2, myotonic face and neck sites, 1x/week/2 weeks, or 1/month, up to 18 months increased ability to voluntarily move, significantly reduced (scores 10 to score 3) back and neck pain, reduced involuntary athetoic (slow writhing), increased motor function in limbs, trunk, vocalization, increased ability to chew and swallow, decreased dysuria (painful urination), and decreased breathing problems.

Red light therapy brain dose

Increase Brain Blood Flow in Vegetative Patient Red Light Dose

Journal:

Focal Increase in Cerebral Blood Flow After Treatment With Near-Infrared Light to the Forehead in a Patient in a Persistent Vegetative State

Wavelength:
830
Irradiance:
11.4
Condition:
Cognition, Traumatic Brain Injury
Outcome:

830 nm, 11.4 mW/cm^2, 1800 s, 2/day/73 days (146) improved blood flow and correlated with patient regaining cognition.

“The patient showed some improvement in his neurological condition by moving his left arm/hand to reach the tracheostomy tube, post-LED therapy.”

Red light therapy brain dose

Reduce Autism Irritability Red Light Dose

Journal:

Effects of Low-Level Laser Therapy in Autism Spectrum Disorder

Wavelength:
635
Irradiance:
15
Condition:
Autism, Emotion
Outcome:

Reduce autism-related irritability.

 

Red light therapy brain dose

Decrease Anxiety Red Light Therapy Dose

Journal:

Transcranial Photobiomodulation With Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study

Wavelength:
830
Irradiance:
30 mW/cm^2
Condition:
Anxiety, Emotion
Outcome:

In Generalized Anxiety Disorder (GAD patients):

  • reduce Hamilton Anxiety Scale (SIGH-A) score
  • reduce Clinical Global Impressions-Severity (OGI-S) subscale score
  • Increase Pittsburgh Sleep Quality Index (PSQI subscale score
Red light therapy bone dose

Bone Fracture Healing Red Light Therapy Dose

Journal:

Therapeutic Outcomes of Low-Level Laser Therapy for Closed Bone Fracture in the Human Wrist and Hand

Wavelength:
830
Irradiance:
60
Condition:
Bone Fracture
Outcome:

Decrease wrist fracture healing time.

Red light therapy brain dose

Depression and Alcoholism Red Light Therapy Dose

Journal:

Use of low-energy laser as adjunct treatment of alcohol addiction

Wavelength:
514, 633
Irradiance:
100 mW/cm^2, 25 mW/cm^2
Condition:
Addiction, Alcoholism, Depression, Emotion
Outcome:

Improve beta endorphin plasma concentration and Beck Depression Inventory Fast Screen score in alcoholics seeking help quitting.

Study red light sleep dose

Red Light Through Eyelids Reduces Sleepiness Dose

Journal:

Effects of red light on sleep inertia

Wavelength:
615, 635
Irradiance:
35
Condition:
Sleep
Outcome:

Reduce morning sleepiness known as “sleep inertia” without reducing melatonin.

Red light therapy wound dose

Contact Dermatitis Resolution Red Light Dose

Journal:

Is light-emitting diode phototherapy (LED-LLLT) really effective?

Wavelength:
830
Irradiance:
100 mW/cm^2
Condition:
Dermatitis
Outcome:

Clear treatment-resistant contact dermatitis that started after alpha-hydroxy acid (AHA) peel compound application.

Red light exercise dose

Lower Exercise Stress Response Red Light Dose

Journal:

Oxidative Stress in Muscle Diseases: Current and Future Therapy 2019

Wavelength:
810
Irradiance:
100
Condition:
Exercise
Outcome:

Ddecrease post-exercise stress on 10 data points

Science study Red light therapy skin dose

Strengthen Skin Wound Barrier Red Light Dose

Journal:

Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential

Wavelength:
Range
Irradiance:
40 mW/cm^2
Condition:
Wound
Outcome:

Promoted recovery of wound epidermal barrier.

Healthy skin

Four Infrared Light Doses for Better Skin (study summary)

Journal:

Infrared and skin: Friend or foe

Wavelength:
660, 830, 805, 900
Irradiance:
50
Condition:
Collagen, Wrinkles, Aging Skin
Outcome:

Infrared Affect on Skin Review Rationale

Photobiomodulation researchers examined near infrared (NIR) studies that had resulted in damaged skin. The researchers determined that near infrared caused damage when applied in strong doses. Low dose NIR spread over time reduces wrinkles, produces collagen, and causes no harm.

Infrared Affect on Skin Review Hypothesis

Previous studies found near infrared photobiomodulation (PBM) damage because the doses were too high.

Infrared Affect on Skin Study Method

Examine PBM studies that showed near infrared light skin damage to correlate light doses with skin damage.

Infrared Affect on Skin Study Summary

In a review of Near Infrared photobiomodulation (PBM), use of near infrared light only caused damage when the dose was too high.

Near infrared light between 760 and 1,400 nm wavelengths rejeuvanates skin when applied in low (but not too low!) doses over time.

For more collagen and fewer wrinkles, use any of these wavelengths as frequently as once per day, at a dose of 20 to 50 mW/cm^2.

  • 600 nm
  • 805 nm
  • 830 nm
  • 900 nm

Infrared Review of Skin Effects Study Conclusion

  • Ultraviolet (UV) and some infrared light frequencies are always harmful to the skin
  • Near infrared with wavelengths between 760 nm and 1,400 nm are healthy when administered in a dose of 50 mW/cm^2 using any of these wavelengths: 660 nm, 805 nm, 830 nm, or 900 nm
  • Wavelengths mentioned in the previous bullet point induce more collagen and elastin; result in better skin tone and fewer wrinkles.
  • Use no more than 50 mW/cm^2, once a day or less.

“The body will absorb only so much energy before that energy damages the cytochrome cells.”

In every study reviewed, IR-A induced damage when the total energy absorbed was higher than one would receive from morning or evening sun.

Sunlight infrared is healthy when the shadows in the morning and evening, when the shadows are long. Noontime infrared creates oxidative stress. To get healthy artficial  infrared light, use no more than 50 mW/cm^2 of 660 nm, 805 nm, or 830 nm wavelength light.

EMF Channel Remarks on Infrared Review Publication

NIR frequencies can penetrate epidermis, dermis, and subcutaneous tissue.

To visualize what this means, the NIR light reaches all of this:

  • epidermis: immune system and pigment cells
  • dermis: hair follicles, nerve endings, sweat glands, oil
  • subcutaneous tissue: connective tissue, fat, blood vessels

You can’t see infrared light. If you can feel it as heat, you’re getting too much.

Interestingly, if you use a high dose but simultaneously cool the skin, you can prevent thermal damage.

But this method isn’t tested for creating a healthy response. We just know that it prevents damage, not if it creates collagen and smoother skin.

About the EMF Channel Light Dose Database

Many people purchase red light therapy or neuromuscular electrical stimulation devices without knowing optimal doses for the results they want to see. The right dose is especially key to light therapies, which have optimal windows of wavelength and energy delivered. Treatment doses outside of those windows will nullify results or harm the user. I took the results from successful EMF studies when these studies included:

  • Photobiomodulation (Red Light Therapy, Blue Light Therapy, Low Level Light Therapy)
  • Transcutaneous Electromagnetic Nerve Stimulation (TENS)
  • Pulsed Electromagnetic Field (PEMF) Therapy
  • Neuromuscular Electrical Stimulation (NMES)

Many studies do not report exact dose parameters they used. They are therefore not included here, even the study reported a therapeutic result.

Light Dose Parameters
Term
Parameter
Time
Seconds
Power
milliwatts (mW) or Watts (W)
Total Dose Energy
joules (J) = power x time = Watts x seconds
Wavelength
nanometers
Frequency
Hertz (Hz)
Spot Size
cm(2) (centimeters squared)
Duty Cycle
percentage of time light source is on during one cycle
Power Density (or Intensity)
Watts per centimeters squared (W/cm(2) = power / probe size
Energy Density (Fluence)
jules per centimeters square (J/cm(2)) = total energy delivered by the probe size

Source: Turchin, Curtis. Light and Laser Therapy: Clinical Procedures 6th Edition (p. 16)

Image by Thomas-Suisse from Pixabay