Red Light Halts Brain Memory Tissue Damage (study summary)

STUDY INFO

TITLE
Photobiomodulation (660 nm) therapy reduces oxidative stress and induces BDNF expression in the hippocampus
AUTHOR(S)

Jin-Chul Heo, Ji-Ae Park, Dae-Kwang Kim, and Jong-Ha Lee

IN VITRO HUMAN RESULTS
No
JOURNAL
Scientific Reports
DATE
July 12, 2019

RATIONALE

Red Light Therapy (RLT) is already successful treating neurlogical and brain damage.

This study tested whether RLT could prevent hippocampal oxidative stress by reducing oxidative stress.

The goal is to treat disorders that lead to nerve damage.

HYPOTHESIS

Photobiomodulation (PBM) decreases oxidation and increases brain derived neurotropic factor (BDNF).

STUDY SUMMARY

This study showed that low power red LED light can decrease brain stessors, and increase neural regeneration.

Investigators applied 660 nm (red) light at a low irradiance of 20 mW/cm^2.

METHOD

Researchers induced mouse oxidative stress. They treated hippocampal cells with 100, 300, and 1,000 micrometers H2O2.

They treated the test group with 660 nm LED.

They tested all groups  for oxidative stress.

 

RESULTS

The low energy red light application created these results:

  • inhibited hippocampus cell death by 1.3% to 15.7%
  • reduced oxidation and oxidative stress
  • increased ERK (extra-cellular signal related kinase) and CREB (cAMP response element binding protein) communication
  • increased BDNF (brain derived neurotropic factor),which promotes neural regeneration

 

CONCLUSION

This study showed that low power red light is a non-invasive and painless brain enhancement modality.

Red Light Therapy (RLT) decreased oxidative stress and increased hippocampal cell survival.

Photobiomodulation (PBT) is already being used to treat degenerative and traumatic brain injuries.

RLT produced BDNF  [brain-derived neurotrophic factor]. BDNF promotes neural cell survival.

Low level RLT is potentially useful for treating Alzheimer’s Disease.

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